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In order to narrow the candidates, we took into account the experimentally observed positive feedback by ERK (Figure 1).
These seemingly contradictory results may be reconciled in part by the observed positive feedback effect on initial cell membrane permeabilization due to toxin insertion.
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We did not observe positive feedback between DNA methylation and H3K9 methylation.
Similarly as before, we did not observe positive feedback between DNA methylation and H3K9 methylation, since no changes in DNA methylation levels were observed after targeted H3K9 methylation (Additional file 1: Figure S8B).
observed a positive feedback loop between IGFBP2 and ER- α, where stimulation of ER- α increased IGFBP2 production and in turn IGFBP2 production influences the expression of ER- α. 30 isFbelievedelieved to mediate ER- α expression in an IGF-independent function through interactions with integrins.
While we have observed that a positive feedback relationship is present between SALL4 and OCT4, the strong self-repression of SALL4 seems to be the "break" for this loop.
Largest P3b amplitudes were observed after explicit positive feedback (all p-values < 0.001).
The loss of flexibility observed on reducing positive feedback is therefore mainly a consequence of the output ellipsoid contracting along this axis (accompanied by a roughly proportional contraction along the others).
Using this measure for one set of input conditions (Table S3, Additional file 1), we observed that high positive feedback (h = 8, a f n o r m = 0. 81 ) did indeed significantly outperform low positive feedback (h = 2, a f n o r m = 0. 0. ).
We uncover customer demand pull as the initial trigger and observe how a positive feedback loop sets in subsequently, leading to a further increase in the use of selective revealing.
Interestingly, at the OFF state, only a weak positive relation between NARoff and sensitivity can be observed for the single positive feedback module according to our analysis (Supporting Information, Section B.6).
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