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Notably, responses in these trials range within a previously observed paradigm: in biologic-naïve patients, ACR20/50/70 responses from 59%to7171%, 40%to44%4%, and 23%to28%8%, respectively, compared with 50%, 28.8%, and 12.4%, respectively, in anti-TNF incomplete responders.
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However, the intrinsic limitations of in vitro cell culture, such as the inability to reflect cellular organization within tissues, has distanced observed paradigms from possible clinical developments.
► We observed a paradigm shift from predicting to exploring the future.
We observed several paradigm shifts reflecting the learning process of scientists and policymakers: (a) from flood control to integrated water management, (b) from predicting to exploring the future with integrated scenarios, and (c) from fighting water to accommodating and adapting to water.
Moreover, recent experimental work seems to suggest that frontal activity observed during paradigms investigating conscious perception is the result of task related demands or motor report54,55,56,57.
For example, both increases and decreases in the reinforcing efficacy of cocaine have observed following paradigms that produce tolerance to cocaine effects at the DAT.
The dissonance we observed between paradigms used to describe and evaluate the non-medical use of MPH for performance enhancement could have profound healthcare, ethics and social implications and consequences.
From a societal perspective, we can observe a paradigm shift.
The protection observed challenges the paradigm whereby circulating antiviral antibodies are required for protection against HIV-1 infection and may serve in designing a human vaccine against HIV-1-AIDS.
Surprisingly, low dose of MWCNT stimulated S. mytilus growth [128], supporting the paradigm observed in later field study [129].
It is possible that the sub-toxic concentrations of CNT introduce a slight stimulatory effect by up-regulation of repair mechanisms, a paradigm observed for other pollutants discussed by [130].
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