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This phase II trial was not designed to compare the antitumour activity observed on Schedule 4/2 and the CDD schedule.
In both HNX14C and HNX22B cell lines, synergistic growth inhibition was observed on schedule 2, whereas schedules 1 and 3 demonstrated antagonistic effects.
A higher ORR was observed on Schedule 4/2 (11.1%) vs CDD (2.1%), and a higher median OS was observed on the CDD schedule (37.1 vs 23.4 weeks, respectively).
Depending on the number of objective responses observed on Schedule 4/2, sample size for the CDD cohort was determined using either a two-stage design (if ⩽5 confirmed objective responses were observed) or a single-stage design (if ⩾6 confirmed objective responses were observed).
However, despite the low overall response rate, we were encouraged by the time-to-event results obtained, which we feel are concordant with a signal of activity and with time-to-event data observed on Schedule 4/2 (4 weeks on treatment followed by 2 weeks off; Socinski et al, 2008).
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This diversity loss cannot be recovered by forward-error-correction channel coding, since the DFT-spreading applied with SC-FDM effecausesy canses averaginging over SINR observed on all scheduled subcarriers according to.
However, if a CD4 count observed on the monthly schedule indicated treatment initiation but that CD4 count was not observed on the 12-monthly CD4 count schedule, then that participant would not have been identified for treatment initiation under the less-frequent CD4 observation until sometime later.
A decrease in responses emitted and rewards received was observed on the PR schedule at the 5, 10, and 20 μg doses.
At the end of the study, if ⩾5 objective tumour responses were observed on the CDD schedule, then the null hypothesis was to be rejected.
The effect of irrigation scheduling was observed on: apical shoot growth rate (GRAS), branch cross-sectional area (BCSA), canopy volume (CV), annual length of accumulated growth (ALAG) and productivity.
For example, if each random low CD4 count that happened to be observed on a monthly, but not yearly, schedule led the person to be started on treatment early, then the optimal regimen would be reduced with more frequent observation.
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