The observed objective response rate of 41%9595% CI, 29 53) was judged to be higher than with cisplatin and docetaxel alone.
The observed objective response rate of 15.2% and median overall survival of 9.3 months in this study compares favourably with other trials of patients with advanced CRC previously treated with 5FU and irinotecan.
With regard to clinical trials, Morse and colleagues have observed objective responses in patients with metastatic disease, including breast cancer, following immunization with dendritic cells (see below) pulsed with an human leukocyte antigen (HLA -A2 restricted peptide of CEA [ 6].
We did not observed objective tumour responses, as it was the case in the Vosika [ 28] or de Bono [ 27] studies, but disease stabilisation occurred in 3 patients including 2 patients with colo-rectal carcinoma and one patient with non-small cell lung carcinoma.
Also distinct from previously observed objective risk coding in dopamine neurons [ 47], orbitofrontal cortex [ 35, 48], and anterior dorsal septum [ 49], the current data, consistent with our previous observations [ 17], demonstrate the incorporation of risk into value coding in a manner consistent with traditional theories of utility.
They did not observe objective responses (OR), although 14 patients (53.8%) had SD.
Of interest, and in agreement with the tissue-based analysis discussed below, we did not observe objective responses by RECIST.
With regard to clinical activity, we did not observe objective radiographic responses but did observe evidence of metabolic inhibition and prolonged disease stabilisation in some patients, which is noteworthy in the light of a median of five previous treatment lines.
RXTE was successful in achieving its original observing objectives of large area and high time resolution observations with broadband (2 200 keV) spectra, scheduled flexibly enough to enable observations of targets of opportunity on any timescale greater than a few hours.
