Then, in consideration of the natural history of pediatric obesity and of the current absence of universally acknowledged and shared goals for its treatment, we scored clinical outcome as follows: when no BMI% increase was observed (Normal-weight: BMI <85th percentile at follow-up).
In line with differences in cholesterol metabolism in lean and obese subjects [18], the reduced expression of the transporter was weight-specific and observed in normal weight individuals only [16].
A negative association between sOB-R and modified MetS was observed in normal weight individuals only (Model 1), and the significant association disappeared following adjustments of FMI or trunk fat percentage (Model 2 and 3).
Conversely, a nonsignificant direct association with WHtR was exclusively observed among normal weight women.
No differences in sICAM-1 by MMW were observed among normal weight or overweight individuals.
Similarly, no difference in distant metastasis between the two treatment arms was observed in normal weight patients.
Differences between workdays and days off with regard to VPA were observed for normal weight women; VPA10 min was higher during days off than on workdays.
> -wrap-foot> Hazaratiosios adjusted for sex, waist-hip-ratio, smoking, education level, total serum cholesterol, HDL cholesterol hypertension and diabetes; py: person-years; CI: Confidence interval To investigate whether the lower risk of mortality observed among normal weight APOE*2 carriers was due to a lower risk of mortality from CHD, we calculated the HRs separately for CHD mortality.
Among men, the increase in use of health care was largest among the obese people, but significant increases were also observed among the normal weight and overweight people (data not shown).
This protective effect seems to be limited to mortality from CHD. Analyses within BMI strata demonstrated that this genetic advantage of APOE*2 was observed only in normal weight individuals, but not in overweight and obese APOE*2 carriers.
Weight reduction observed in overweight/obese women alone was also modest −0.5%9595% CI: −1.7, 0.8), and other changes observed in normal-weight weight women were similar to those observed in the rest of the participants (Additional file 1: Table S1).
