Exact(1)
We unexpectedly observed no synaptic ribbons in the extramacular hair cells.
Similar(59)
In primary neuronal cultures from non-tg mice expressing only EGFP, we observed no toxicity after synaptic or extrasynaptic NMDAR activation.
Although we observed no differences for the Timp1 (neuroprotection), Ccl2 (neural differentiation), and BDNF (synaptic plasticity) gene expression, there was an overall increase in their fold-change with approximately 1.2 2 fold after chronic vmPFC HFS.
We further observed no obvious differences in axonal elongation (calbindin), dendritic arborisation (MAP1A or calbindin), distribution of synaptic protein (synaptophysin), and ciliogenesis (Arl13b) in the cerebrum or cerebellum (supplementary material Figs S2, S3).
In line with this finding, we observed no significant differences in immunoreactivity against Neuronal N (NeuN) and synaptophysin (SYP), two well-established markers of neuronal and synaptic integrity, between Hdac6 −/− mice and wild type littermates (Fig 1F).
'+': plaque observed; '−': no plaque observed.
In studies of axotomy-induced synaptic degeneration at the neuromuscular junction WldS mice older than 4 months began to lose their synaptoprotective phenotype, with no synaptic protection observed at all in mice older than 7 months [33].
However, no synaptic connections were observed in control cords receiving double hemisection injury.
In contrast, no synaptic events were observed when recording s were made from HEK293-NL2 cells (n = 6).
Five minutes after termination of LFS at 0.3 Hz, no synaptic depression was observed (ANOVA, F 1,70) = 3.40; P = 0.70, n = 7, Fig. 3 C ). LFS at 0.5 Hz also had no significant effect on the fEPSP (ANOVA, F 1,54) = 8.14; P = 0.91, n = 7, Fig. 4 C ). LFS at 1 Hz (600 pulses) was characterized by an initial FF of maximally 190 ± 18.2% that endured for approximately 300 s.
Under these conditions, no synaptic plasticity occurred (Figure 11C squares).
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