In a recent study, Cyp2c29 was identified as the most likely candidate for inter-strain differences in warfarin metabolism by haplotype association mapping, but no strain-specific polymorphisms were identified in the coding region of the gene and no differences in gene expression were observed [84].
No strain-specific genes and no plasmids were found among sensu stricto strains after sequencing of five strains [ 8, 11].
Contrary to expectations, we also observed a strain-specific trend of anxiolytic effects associated with the EHLP.
Along these lines, it is especially notable that half of the environment-responsive transcript changes we observed showed strain-specific effects.
The multiple alignments showed the existence of nine large locally colinear blocks (LCBs); however, it was observed that strain-specific regions were also present within LCBs (white segments in Additional file 1), which may harbor specific adaptations of each bacterium, as it will be further discussed in the plasticity segment section.
Given the considerable genetic heterogeneity of P. falciparum parasites circulating in the field, these studies may fail to observe vaccine strain-specific efficacy unless this is specifically analyzed.
Polymorphisms distributed among polyphyletic sets of strains was the most common pattern of genome alteration observed, indicating that strain-specific genome variability is significant.
By generating DGE profiles for liver from three individuals from each strain, we observed strain-specific differential miRNA expression for 4 miRNAs.
reanalyzed the data from the first influenza vaccine trial for observed and predicted strain-specific infection incidences from logistic regression fits of the log2 titers of strain specific antibodies.
No characteristic differences of serotype specificity, geographical distribution, STs, or topological pattern from long-PCR analysis (additional file 6) was observed in these strain-specific regions, indicating that these regions might be acquired by chance as suggested by Waterhouse and Russell [ 28].
