The authors observed no major genetic effects of the analysed variants on depressiveness.
In this study, we observed no major side effects in the mice treated during the 8 weeks.
We observed no major adverse events.
We observed no major departures from proportionality.
Of note, this rescue observed despite EDARADD B overexpression has no major effect on zebrafish development.
No major effect was observed in STAT3 phosphorylation levels using Akt or ERK inhibitors.
After enzymatic treatment the tissue appears slightly disorganised, but no major effect is observed.
Although no major effect was observed for MMP-2 activity in RASFCs, it was strongly upregulated by the combination of IL-17A/OSM in primary chondrocytes compared with either cytokine alone.. IL-17A upregulates MMP-1 production in human cartilage cultures; however, this did not reach significance.
With respect to AFEX pretreatment, earlier reports did not observe any major effect on cellulose CrI under current AFEX conditions [ 26].
We did not observe any major effect of PTEN hypermethylation on overall survival, even though MM subgroup patients with aberrant PTEN had a tendency to superior survival with respect to unmethylated patients according to their clinical stage and laboratory parameters.
