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We observed no additional risk beyond traditional steroid epidurals.
One study observed no additional benefit of combined nebulized and intravenous CMS therapy [55], whereas the two others observed a higher cure rate compared to intravenous therapy alone [56, 57].
We observed no additional diagnostic benefit of short duration pretreatment procedures on direct sputum smears performed using auramine staining, which is the routine method in our center.
This was not the case in our population where we observed no additional risk of treatment failure for infections with ≥ three mutations in the dhfr gene compared to double mutations.
We observed no additional mutation of the INHBA gene in these 43 patients.
We observed no additional reduction PRBC transfusions in patients administered doses greater than 60 90 μg/kg.
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We observe no additional benefit of adding primaquine (at 0.25 mg/kg) to the A-L combination, consistent with two recent Cochrane reviews which concluded that there was no clear evidence as to whether primaquine (in combination with an ACT) can directly reduce onward transmission in an area where malaria is endemic, even if it significantly reduces gametocyte prevalence (44, 45).
There are also a few cases shown in Table 1 where a typical or nearly typical ATP-binding motif is observed, but no additional molecules are observed in the crystal structures.
Subsequently, we investigated whether the changes in sense and antisense transcript levels between times points are correlated and observed no global correlation (Additional file 5: Figure S3).
Furthermore, no dominant neutral loss of phosphoric acid should be observed when no additional serine or threonine phosphorylation was annotated to assure phosphorylation of a tyrosine residue.
In this study, we observed that no additional binding modes but these two were adopted for the recognition of the H4K20me2 and H3K9me3 peptides as well.
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