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It is therefore possible that the phenotype we observed might also result from a cellular stress response in the RPE.
In addition, the differences in expression between the two mPRs here observed, might also be due to the lower frequency of stage IV follicles in treated females where the α isoform is commonly more abundant [32], [33].
As indicated by these reports, the stronger antibody response in the higher seasonal influenza antibody level group, as we observed, might also be due to the priming effect of the pre-existing seasonal influenza immune response, an assumption also supported by the observation that serum IgG against HA increased dramatically between day 5 and day 10 after vaccination (Figure 1).
These results might indicate that degeneration associated with TDP-43 is unrelated to the cytosolic inclusion formation, however the dose-dependent TDP-43 neurodegeneration observed might also reflect degeneration associated with over-expression of TDP-43, perhaps related to the RNA directed biological function of the protein.
The difference observed might also be due to the difference in detection level of the techniques employed.
Although the wide variance of the TMRCA calculations might be affected by the scarce sequence information available, the differences observed might also be related to their biological differences.
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Although we have, thus far, only considered gene duplication, the homogeneity of Abpa genes we observe might also have arisen because of non-allelic gene conversion, as previously observed for interferon-alpha [ 32] and globin [ 33] genes, for example.
Variation in IGFBP-3 levels observed might account for this and also for individual variation in yearly increment of mandibular growth.
In addition, since CHWs were feeling observed, they might also have been more careful in their procedures [ 27].
The significant genetic differentiation of spatially separated Caullerya populations observed here might also be influenced by processes other than limited gene flow.
The milder effects we observe here might also suggest reduced penetrance and/or a later age of onset on hearing as suggested by others.
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