However, we observed marked ambivalence with regard to other issues.
In doing so, we observed marked differences with a total of 34 differentially expressed genes across the different brain regions (Fig. 3; for fold-differences and P values see Additional File 1).
We observed marked toxicity, with Grade 3 and 4 diarrhea (35%) requiring frequent dose reduction, especially of capecitabine, resulting in a low relative dose intensity for capecitabine of 79%, although the dose reduction did not translate into a reduced frequency of Grade 3/4 diarrhea.
A recent German RCT observed marked clinical improvement with acupuncture and concluded that acupuncture is relatively cost-effective with regard to quality of life [ 15].
However, we observed marked H4K16ac staining, colocalising with the GRC body during leptotene, zygotene and reaching a maximum at pachytene (Fig. 4d).
We evaluated the status of apoptotic markers in Figure 2C and observed marked mitochondrial-mediated apoptosis with cleavage of caspase 3 and PARP in sensitive cell lines compared with resistant cell lines.
In that study we observed marked enrichment in proteins associated with endocytosis and the cytoskeleton in lipid raft microdomains of cells treated with PDGF, consistent with other studies linking PDGF to alterations in cell morphology and the actin cytoskeleton.
In contrast, we observed marked differences between asthmatic children with and without rhinitis in the frequency of wheeze attacks, wheeze limiting speech, unscheduled visits to family doctor because of poor asthma control, and missed school days (Fig. 2).
The need for safe and structurally defined immunomodulators and adjuvants is increasing in connection with the recently observed marked increase in the prevalence of pathological conditions characterized by immunodeficiency.
Consistent with elevated ERG levels we observed marked decreases in prostein.
