Exact(4)
For our two broader CVD syndromic definitions, we observed low sensitivity and PPV (<0.40) when compared to the corresponding ED ICD-9 discharge code, though specificity for both definitions was high (>0.95) (Table 3).
The observed low sensitivity of A1C ≥6.5% to diagnose type 2 diabetes adds to the debate about its screening utility.
The selective sampling of fluid-producing ducts may be one of the contributing factors underlying the observed low sensitivity of cytology to detect malignant cells in breast fluids.
A number of factors that may explain our observed low sensitivity include the small sample size and the many errors made by participants during the testing phase rendering most of the test results invalid.
Similar(56)
However, a number of other studies in specific patients populations (e.g. patients with cardiovascular diseases) also observed low sensitivities and comparable specificities as we observed[ 13, 17, 27].
The observed low level of sensitivity of microscopy compared with that of PCR for identifying P. falciparum infections is similar to findings observed elsewhere (12 – 12 ).
In summary, we observed the low sensitivity of Panbio Early Dengue NS1 ELISA in detecting dengue infection in samples collected during our surveillance in Indonesia.
However, we observed very low sensitivity of NS1 in samples infected by DENV-4 (Table 2), and that DENV-4 serotype was indeed significant in influencing the NS1 sensitivity (Additional file 1: Table S1).
High number of false positives due to non specific labelling was still observed and low sensitivity and specificity contribute to the conflicting results previously reported in detection of disseminated tumour cells [ 25, 28, 29].
For the specific prediction of disease progression, we observed very low sensitivities of 7.1% and 21.4% at 100% specificity for the VEGF levels available before second and third cycles of chemotherapy, respectively.
We observed a relatively low sensitivity of NS1 ELISA for dengue detection on RT-PCR-positive dengue samples.
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