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A survival benefit of the therapy after adjusting for known risk factors was observed (hazard ratio, 0.48; 95% CI, 0.41 0.56; P<0.41 0.56
In supplementary analyses including the 1308 people with a history of ischaemic heart disease at baseline, similar results were observed (hazard ratio 1.04, 0.95 to 1.13, adjusted for age and sex).
If other unknown confounders explain the strong and significant relationship we observed (hazard ratio 2.69 [95% CI 1.10 6.60]), it would have to be a particularly large yet unknown confounder for the results we observed.
According to the MACE+ criterion, 95/5,794 events in the IDeg/IDegAsp group versus 37/3,461 in the comparator group were observed (hazard ratio 1.30; 95% confidence interval 0.88 1.93).
The rate of LDAE did not differ between those starting ART with a CD4+ cell count 351 499 and less than 350 cells/μl [relative rate 0.90, 95% confidence interval (CI) 0.74 1.09)], but an increased risk of ART discontinuation was observed (hazard ratio 1.58, 95% CI 1.10 2.27).
Interestingly, a protective effect of both IRF5 rs2004640 GG and IRF5 rs10954213 GG genotypes against the risk for CV events after adjusting the results for sex, age at RA diagnosis and traditional CV disease risk factors was observed (hazard ratio (HR) = 0.6, 95% confidence interval (CI) = 0.38 to 0.92, P = 0.02; and HR = 0.58, 95% CI = 0.36 to 0.95, P = 0.03, respectively).
Similar(29)
Assuming that model (1) is the true one, the consequences of omitting Z(2) on the formulation of the observed hazards ratio relative to Z(1) is described below.
However, all individual studies, with few exceptions, observed elevated hazard ratios for each prognostic factor.
Furthermore, we observed that hazard ratio in survival analysis was increased from 1.878 to 12.784 in patients with a metastatic lymph node ratio of 1 39%, 40 79% and ≥ 80%.
We observed that hazard ratios for individual species varied depending upon whether we used the entire or a subset of the data.
Ashbeck et al. [ 18] examined benign breast biopsy diagnoses in the New Mexico Mammography Project and observed a hazard ratio for breast cancer of 2.28 (95 % CI 1.64 3.17) in patients with SA.
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