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Toxicity was moderate in the group of patients with BM, the most frequently observed grade 3 or 4 side-effects included thrombocytopenia (17%), granulocytopenia (17%), lethargy (17%); other neurological (17%) and other genitourinary toxicity (17%).
Hematological toxicity was within ranges reported by anthracyclin-based schemas, with no grade 3/4 thrombocytopenia, and 15% grade 3/4 anemia; nevertheless, we observed grade 3/4 neutropenia in 35% of cases, which appears to be higher than that reported by other authors [23], [25], [33] [38].
The second DLT observed, grade 3 diarrhoea, affected only one patient.
The most frequently observed grade 3/4 nonhaematological toxicities were anorexia and asthenia.
Thrombocytopenia and neutropenia were the most frequently observed grade 3 or 4 AEs (Table III).
The most frequently observed grade 3 or 4 toxicities were neutropenia (13%) and thrombocytopenia (13%).
Similar(18)
The observed graded mechanical properties in stainless steel 304 allow the opportunity for varying the processing conditions to design parts with locally optimized or functionally graded mechanical properties.
We observed grades 2 nd 3 fibrosis in our studies.
The main nonhaematological toxicities are summarised in Table 4 >: in no case did we observe grade 4 nonhaematologic toxicities or cardiac adverse events.
The DLTs observed were grade 4 diarrhea, grade 3 esophagitis and grade 4 hematological toxicities.
However, the biggest change was observed from Grade 7 to Grade 8 for both genders.
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