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In eight of the included studies, SCCs that had apparently completely responded to photodynamic therapy initially were observed for recurrence.
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Furthermore, this was observed for recurrences that included both DCIS and invasive disease and when recurrences were restricted to invasive disease.
All were observed for recurrences of P. vivax malaria (up to six months) and all trials tested people for G6PD enzyme, and excluded patients who were deficient.
When stratified by tumour type a significant difference (P=0.004) in cumulative mortality was observed for recurrences, where Ewing sarcoma survivors had nearly double the cumulative mortality at 35 years post diagnosis (osteosarcoma: 8.5% vs Ewing sarcoma: 16.7%).
It should be noted that the rate of hospital admission may be affected by management protocols as well as individual medical need, as protocols for severe hypoglycaemia induced by SU therapy mandate admission to observe for recurrence of the hypoglycaemia, but such admissions, if uncomplicated, should be relatively short.
Similar results were also observed for locoregional recurrence, with 2-year locoregional recurrence rates of 22% (4/18) and 39% (35/90),respectively (HR = 0.4; 95% CI 0.1 to 1.4; p = 0.3).
Two days after tumor resection, mice were allocated to 1 of 2 groups as previously described and observed for tumor recurrence (Figure 8D).
Patients were observed for disease recurrence at least once every 6 months for the first 5 years after the surgery and thereafter once every year.
Patients were observed for disease recurrence at least once every six months for the first 5 years after the surgery and once every year thereafter.
Patients were observed for disease recurrence and death at least once every 6 months for 5 years after surgery and yearly thereafter.
The only independent prognostic factors observed for local recurrence were stage and involved pelvic nodes, and for distant metastases, size of centre, involved pelvic nodes and high dose rate brachytherapy.
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