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Exact(16)
We observed flexibility of the N-clasp domain.
Consequently, we regard the observed flexibility not as a behavioral response to "active" male desertion, but rather as an evolutionary "backup" to partner loss.
The observed flexibility could be essential to stabilize the transition state during methyl-group transfer.
T7 sits adjacent to another thymine (T8) and the altered stacking energy between these bases might contribute to the observed flexibility at that position.
The relatively direct routes followed by displaced birds toward the staging areas used by non-displaced birds, suggest an important goal-oriented strategy during migration, and the observed flexibility in response to displacement is unlikely to be based on variation in the inherited spatio-temporal migration programme alone.
Model predictions for linking numbers and sizes of LacI-DNA loops can be tested using multiple experimental approaches, which coupled with theory could address whether proteins or DNA provide the observed flexibility of protein-DNA loops.
Similar(44)
Their smaller and more symmetrical distribution about the initial models suggests that for weak binding bridges we are observing flexibility and for strong binding bridges we are observing an aspect of the working stroke of myosin heads functioning in situ.
We similarly observe flexibility of the IBR domain in the ∆86 130 Parkin structure.
Mr. Daalder observed, "Maximum flexibility is a two-way street".
Additionally, observed conformational flexibility of the Arg463 and Arg536 side chains likely regulates GCPII affinity toward different inhibitors and modulates GCPII substrate specificity.
The observed Trp312 flexibility equates to a molecular shovel action, which leads to the expulsion of the donor aglycone leaving group from the catalytic site.
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