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Malaria was defined as symptoms of fever or observed fever together with a parasitemia of >2500 parasites/µl.
With respect to the primary endpoint of the study, the occurrence of severe (grade 3) systemic reactions occurring for up to 7 days after each vaccination, one severe event was observed (fever) in the RTS,S/AS01B group and none in either the RTS,S/AS02A candidate vaccine group or the rabies control group.
Malaria episodes were defined as the presence of fever (≥38°C) and/or malaria-like symptoms with parasitemias higher than a given threshold value above which an individual had a significantly higher probability that the observed fever was due to malaria.
A possible additional contributory factor that may be of importance is the observed fever response.
The observed fever on days 1 and 2 p.i. was possibly a response to components of the inoculation medium since goats receiving medium only (Wesonga, unpublished data) also responded in this way.
Similar(55)
Candidemia: patients with fever >38 °C observed, or fever of ≥37.5 °C that continues for 1 h or more despite the use of antibiotic therapy and positive results for the (1,3 -β- D -glucan test.
In the univariate survival analysis, we observed postoperative fever patients were more likely to recur than those without fever (P = 0.0027).
However, we observed that fever was not statistically associated with viral shedding duration (i.e., those HCP who had a fever were not more likely to be positive by real-time RT-PCR or rapid culture longer than those HCP who never had a fever).
The main symptoms observed are fever and haemorrhage as well as cough, diarrhoea and vomiting.
They observed good fever control, but also a decrease in blood pressure in most patients.
The common toxicities observed were fever (56%), nausea (37%) and diarrhoea (33%).
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