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If no additional DLTs were observed, escalation proceeded to the next dose level.
If no DLTs were observed, escalation to the next dose level occurred.
Similar(58)
We observed escalations in vasopressor therapy sufficient to increase the cardiovascular component of the Sequential Organ Failure Assessment score during CRRT in 20.8% of participants on 3.8% of treatment days.
Importantly, there were no AEs observed following escalation to >30 mg/kg per d that were not observed at lower doses before escalation.
The most important difference in comparing DDC-Gal4 and TRH-Gal4 datasets was that we observed some escalation to higher intensity levels of aggression in fights between flies with disrupted 5HT neurotransmission.
If no further DLTs were observed, dose escalation proceeded.
If no additional DLTs were observed, dose escalation continued.
We usually observe an escalation in the presence of several groups of rescue workers and prioritized escalation of their efforts.
Have we failed to observe an escalation of dengue in Africa causing a disease incidence of similar magnitude to that of Latin America, or is dengue truly not spreading into Africa for epidemiologic reasons that are not yet understood?
Dose limiting toxicities were observed in dose escalation trials but a maximum tolerated dose was not established.
No significant changes in the level of willingness to accept pre-pandemic H5N1 vaccine were observed despite the escalation to alert phase 5.
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