On all the basis of the observed end points, we classify PPT as an intermediate compound that is not a long- or short-acting estrogen.
Using observed exposure metrics such as AUC leads to direct correlations between observed end points and exposure measures, which may be the simplest and thus perhaps more often used approach in clinical development.
Given the apical, nonspecific nature of the observed end points in vivo (e.g., decreased fetal body weight, delayed skeletal ossification), which are typical of regulatory guideline developmental toxicity studies in rats and rabbits, more detailed information is required to determine whether vascular disruption is the true mechanism by which a chemical acts.
In contrast to PHHs, HepG2-NTCP cells propagate in cultures, thus the actual infection efficiency of HepG2-NTCP cells may be more likely than not underestimated by the observed end-point HBcAg staining.
The probability of the observed end-point for that particular trial under the model can then be read off this map, and compared to the probability of that same data point under the competing model.
The rest of the histopathology feature values for the three clusters were not informative (all had no observed end-point) and therefore not included as representative features in the phenotypic prototypes.
We observed end-point catalytic activity after incubating substrates to the cells using a luminometer.
If the observed primary end point (composite incidence of AR, graft loss and death by 6 months) for a belatacept-based group was 40%, it was estimated that the two-sided 95% confidence interval (CI) of this incidence would extend from 26.4% to 53.6%, which would be within the general range observed in large LT studies that used CNI-based immunosuppression (21, 22).
Nevertheless, we have shown that the current model adequately describes the observed clinical end points in our data set.
In SAI afferents, NaV1.6 puncta localized to 93% of observed myelin end points (N = 28/30, Figure 1B) and 100% of myelin gaps (N = 9/9, Figure 1C).
