Physician satisfaction with observed efficacy (control of hyperphosphatemia, clinical observation) increased with lanthanum carbonate treatment at week 12, even though control of serum phosphorus levels did not improve significantly over baseline levels.
Hence, the immunotherapy tested herein would have to destroy all neoplastic foci to affect a complete cure, which is perhaps too much to expect; our view is that the stringency of this system has advantages as a readout for therapeutic strategies, in the observed efficacy may be more predictive of responses in the clinic that those observed with subcutaneous tumors.
Though usually ignored, these issues can greatly impact the observed efficacy.
For example, it is very difficult to determine if the observed efficacy is driven by maximum plasma concentration (C max) or minimum plasma concentration (C min) when such a steep drop of DCU plasma exposure is encountered [14].
Studies in BT474 multicellular spheroids suggest that the observed efficacy could be attributed to release of doxorubicin directly into the acidic tumor interstitium from pH-triggered vesicles extravasated into the tumor but not internalized by cancer cells.
[19] However, the observed efficacy in terms of clinical malaria protection in the pregnant women was over 70% within the month after each SP dose.
Moreover, this observed efficacy supports the notion that early rtPA thrombolysis may be favorable in patients with cardiac arrest and confirmed PE or high probability for PE.
In the current study, we measured hASM levels attained within specific regions of the mouse CNS following infusion at this same dose to determine the tissue levels needed for the observed efficacy (n = 8).
While further work will be required to elucidate the precise mechanism at play, the observed efficacy without increasing baseline blood glucose levels may be highly significant in enabling novel therapies.
Although they are based on small numbers, and thus the role of chance can not be completely ruled out, it can be said that the observed efficacy of IPTp of over 60% is of relevance for the global initiatives aiming at reducing the high burden of neonatal and perinatal mortality.
We calculated the expected difference in lifetime HIV risk among circumcised and uncircumcised males given the portion of lifetime HIV risk attributed to heterosexual contact, the prevalence of circumcision in the United States and the observed efficacy of circumcision on HIV prevention in Africa.
