The sociologist Diego Gambetta, in his 1993 book "The Sicilian Mafia," observes that durable criminal enterprises are often woven into the social and political fabric, and part of their "intrinsic tenacity" is their ability to offer certain services that the state does not.
Though less specific and often associated with partial resistance only, disease resistance through antimicrobial compounds has been observed to be durable, since resistance breakdown through deleterious Avr mutations is not possible.
This has to be evaluated in further studies, and in particular correlation needs to be observed between a durable fall in serum ferritin in response to weight control and exercise, and a correction in insulin resistance and reversal of fatty liver.
An overall response rate of 30% was observed, with 17% durable complete remissions (median duration, 777 days), demonstrating the feasibility of combining azacitidine with cellular therapies to augment anti-leukemic responses while minimizing toxicity.
The observed rapid and durable responses to lenalidomide in patients with del 5q) MDS in clinical trials reflect: (1) direct cytotoxicity against the del 5q) clone, leading to high cytogenetic response rates; (2) the ability of lenalidomide to stimulate normal erythropoiesis and BM function, leading to a repopulation of BM with lineages derived from normal CD34+ cells.
Estimated and observed output levels of durable and non-durable manufacturing and TCU are portrayed in Fig. 3.
This is believed to be an important aspect of the durable responses observed in some patients and the field is rapidly moving toward immunotherapy.
Later tests observed trichomes and more durable tissues, such as adaxial leaf surfaces and seed coats (Fig. 2A C).
Indeed, the frequent and durable response observed with the combination of ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) in melanoma is a excellent illustration of this principle.
The inhibition of lung tumour growth observed following PDT was durable; 11 out of 17 mice (62.5%) exhibited no lung tumours 10 days post-PDT, while 12 out of 14 mice (86%) exhibited no lung tumours at 35 days post-PDT and 100% of mice (10 out of 10 mice) were tumour-free at 60 days post-PDT.
