We observed germaria devoid of germ cells in cul-5 mutant ovarioles, which indicates either defects in GSC maintenance or induction of ectopic germ cell death.
These observations further substantiate the possibility that HIFα activation observed in cells devoid of FH activity is likely to be a secondary effect rather than the primary consequence of FH inactivation.
The LVS strain grew normally in CDM+ medium while no growth was observed in CDMx devoid of potassium.
Consistent with roles for RAGE ligands, pharmacological blockade of RAGE with sRAGE protected the cardiomyocytes from H/R damage, similar to the effects observed in cardiomyocytes devoid of RAGE (Fig. 2).
Significant inhibition of the maturation process was observed in oocytes devoid of STIM2 protein.
Additionally, decreased membrane fluidity and increased cholesterol content in lipid rafts were observed in cells devoid of A β [ 68].
Previous studies have observed that water devoid of nutrients is good for starch accumulation, but its molecular mechanism remains unrevealed.
Interestingly, the most prominent cytoprotective effect was observed in cells devoid of Bna3p and Ecm33p, both of which have been found enriched in mitochondria of α-synuclein-expressing cells (Supplementary Table S1).
Involvement of the actin C-terminus in TM binding was observed with actin devoid of two C-terminal amino acids (25); however, the study on actin with three C-terminal residues removed did not confirm this interaction (26).
We observed two gaps devoid of markers larger than 500 kb (on chromosomes 1, 6, 7, 8 and 11) and 12 additional smaller gaps of 300 kb to 500 kb (on chromosomes 1, 2 4, 5, 7, 8, and 9).
