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This pattern is consistent with the observed dependency on Hsp90 ATPase activity.
We can extrapolate an expected achievable identification rate from the observed dependency on experimental parameters like read depth and read length.
The observed dependency on acetylation levels for recruitment of PRC2 is consistent with previous reports that Suz12 occupancy shows an inverse correlation with the presence of H3K27ac at target genes (Pasini et al, 2010b).
To determine whether the observed dependency on TTC5 was specific to the MLL molecular subtype of AML or a more general feature of myeloid leukemia cells, TTC5 KD was initiated in additional human AML cell lines.
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The dependency on the cell density is reminiscent of the community effect, which is the experimentally observed dependency of cell fates on the number of cells in developmental systems, and a similar dependency has also been observed in the regulation of ES-cell differentiation.
We have no explanation for this, and we observed different dependencies on other occasions (data not shown).
The pseudo-count weight can be adjusted by observing that the RCBS dependency on length (i.e. the observed inverse power-law distribution) starts to flatten out for sequences larger than 1000 bp and that this effect is independent on the nature of the sequences analysed (Fig. 1 and Supplementary Fig. S3).
Extra structural anomalies are also observed on temperature dependencies of the M O bond lengths, octahedral tilt angles and atomic displacement parameters, which are evidently caused with the temperature induced changes of spin configuration of Co3+ ions and coupled metal-insulator transition occurred in HoCoO3 HoCrO3 system.
Thus, the FDG-PET findings in this study did not align well with the dose-dependency observed for effects on pharmacodynamic markers of target engagement.
Varying hysteresis is observed due to its dependency on the properties of permeability, porosity and wettability of porous medium.
The travel time and pathline of water particles are also observed to have a dependency on the height of water in the ditches and on the location of source/sink activation area.
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