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The Charlson index was recalculated on either the date of bleed or a random observed date for the bleed and non-bleed patients, respectively.
To address this, we carried out a sensitivity analysis, calculating mean time from diagnosis to AMI in two ways, using the observed date for these subjects and also using the maximum possible interval of 10 years.
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All last observed dates of active work history before December 31 , 1997 for those still alive were considered terminations of active employment.
For survival analysis, OS was measured from the start of treatment to death or last observed date alive (censored observation), and progression-free survival (PFS) was measured from the start of treatment to the date of progression or death, which ever occurred first, or last the date alive (censored observation).
6 For the comparison cohort of patients without upper gastrointestinal bleeding, we followed up from a random observed date.
The index date was the date of the first Hb < 10 g/dL, i.e., first observed date with an indication of severe anemia.
The impact of climate change on life history traits has been observed in many species, including earlier leaf and flower bud burst in plants, earlier breeding date in birds and frogs, and first observed flight date for butterflies (Parmesan 2006; Rosenzweig et al. 2008).
Applying these rules to the 2009 2010 season yielded estimates for each season marker within 2 weeks of the observed dates.
The correlation between forward predicted and observed dates was 0.62, and the observed reporting date fell within the 95% confidence interval for all countries.
The establishment of the assumed Edinburgh Comedy festival in isolation from the Fringe festival saw many tacit threads of standardised practise – a mutually observed ticket release date for example – fall away, and the Fringe entered the deregulated free-market phase of late capitalism.
aThe date for the first observed schizophrenia-related inpatient admission defined the index admission date.
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