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In addition, because leading HTS platforms (in particular Illumina) provide uniform sequence coverage, the copy number of a genomic region of interest can be estimated by comparing the expected and observed coverage in a given genomic region.
However, since all health care workers should be vaccinated, the observed coverage in Germany is disappointingly low.
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> -wrap-foot> Nothatthat a direct comparison with the methods by Chen et al. (2013) and Srinivasan et al. (2013) is not possible, as they are tailored to low coverage plasma sequencing data and require a large number of control plasma samples to evaluate significance of observed coverage variation in the studied plasma sample for CNV calling.
A great improvement was observed in coverage, e.g., increase from 76% with the WGS method to 93% with the pooled BAC approach for chromosome 4.
We observed reduced pericyte coverage in melanomas grown in Shb +/− mice.
At 50x coverage, we detected at least 98% of the insertions and deletions observed at 250x coverage in each isolate.
Regarding the 12-year pattern, a statistically significant increasing trend (p < 0.001) was observed for IV coverage in Portugal since 1998 in the elderly.
We corrected the sequencing coverage observed in CG data by comparing to the coverage observed in 590 genomes available internally at the Institute for Systems Biology, produced with comparable versions of the same technology.
From the point of view of transport demand, it is essential to underline that the large increase in service coverage observed in scenario 1 (more than 2 million people residing in the future metro basin) does not correspond to a large increase in the number of public transport users.
The very high peaks in coverage observed in Figure 4 occur at the end of the DNA fragments (both excised and PCR amplified) and are over-represented in the data set, presumably as a result of sonication bias at the end of DNA fragments.
Kinetic models based on redox-type mechanisms can explain the observed reaction kinetics and can qualitatively predict the changes in CO coverage observed in the DRIFTS study.
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