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Fluorescence from the eGFP-constructs was found in the cytoplasm and in the nucleus of all observed cell lines.
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We observed cell line-specific transcriptional responses as well as a set of common responsive genes.
The genetic and physiological responses underlying the observed cell line-dependence remain to be elucidated.
The observed cell-line specific gene ontology enrichments are consistent with the developmental origins of the cell lines (immune vs epithelial), and culturing conditions (suspension vs adherent).
The differences observed between cell lines with respect to H3K9me2 are consistent with the highly contextual dependence of LSD1 function.
Much like in transiently transfected cells, two phenotypes were observed in cell lines expressing human ZnT3 mutant transporters.
Both full-length and ALT-PTK6 transcripts were observed in cell lines derived from normal prostate and prostate tumors.
Further, ARM390 did not produce substantial receptor internalization in vivo, as previously observed in cell lines [23].
No detectable expression of BRCA1 was observed in cell lines of the basal-like subtype.
HER1 overexpression was observed in cell lines of the basal-like subtype.
A relationship between DNA ICL formation and cytotoxicity was observed across cell lines.
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