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Srivastava thus proposed that the immunogenicity was conferred by tumour-specific peptides associated with the HSPs and this was supported by the observation that a plethora of peptides could be observed bound to gp96 [ 42, 68].
The present study predicts that the number of degrees of freedom in super-families with a lower observed bound should be smaller than for super-families with high bounds.
BSC tools commonly define binding sites as the protein environment surrounding an experimentally observed bound ligand.
Many previous binding site analyses only consider binding sites surrounding an experimentally observed bound ligand.
Density for an aliphatic ligand was observed bound in this pocket in the native structure of MtbHadAB complex (Fig. S2).
Typically, BSC studies make use of known binding sites characterized by surface protein atoms surrounding an experimentally observed bound ligand.
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The revenue to pay for this retooling, though, will have to come from sales of just the sort of cars that the public is no longer buying a situation, the report observes, bound to produce "financial strain".
The revenue to pay for this retooling, though, will have to come from sales of just the sort of cars that the public is no longer buying — a situation, the report observes, bound to produce "financial strain".
Although HNF4αLA interactions were not examined in those studies, the authors mention that the fatty acids they did observe bound to HNF4 could not be removed without denaturing the protein.
We do not observe bound metal in either of these two sites, and E27 and D52 do not appear to be in the correct positions for metal binding.
I observed men bound and tied, whipped, and stimulated with ropes and toys.
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