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As the C terminus is thought to bridge adjacent protomers and as we observed an affect on both R5P binding as well as catalysis, we tested the hypothesis that R288 could pose as an "arginine finger".
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While we did not observe an affect of Sirt1 deficiency on the ability to produce mature oocytes, we did notice a marked decrease in efficiency in generating both 2-cell embryos and live-offspring when performing IVF with oocytes from Sirt1−/− females (Table S1).
Interestingly, despite an increase in the number of PAM neurons during pupal maturation, we do not observe an affect of dFz2/Ca2+ signaling on the number of PAM neurons.
We did not observe any affect of the S65C heterozygote genotype on these levels.
When we analyzed data by controlling for individual baseline performance, we observed a similar overall affect.
To date, the focus of the majority of miRNA publications has been to evaluate gene targets observed to affect a functional response.
First, human regulatory protein inhibits GCK even in the absence of F6P, an affect not observed with the same concentration of rat GKRP.
These give an insight into the effect of gravity, which was observed to affect the Taylor cone, yet interestingly not the fibre jet.
Genotypes of this variant were observed to affect their dopamine binding affinity [ 15], indicating a possible functional effect.
If you were a part of the counterculture, Ms. Lebowitz observed, you affected an indifference to fashion.
Several interactions among processing variables were observed to affect hardening.
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Justyna Jupowicz-Kozak
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