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Relative observed agreement.
The observed agreement between the investigators for the assessment for inclusion was calculated using the kappa statistic.
Furthermore, observed agreement, prevalence and expected agreement were calculated.
Kappa = (observed agreement - expected agreement) / (1 - expected agreement) [ 8].
Where observed agreement was 100% in one direction, Kappa was not calculated.
For this reason, we report percentage observed agreement instead of kappa's.
We observed agreement in prediction in 135 of 198 patients (68%) when considering the three signatures.
The observed agreement between the raters was 73%and88%8%, respectively (Table 4).
Data analysis was mainly based on agreement statistics, i.e., percent observed agreement and Cohen's kappa coefficient.
Overall observed agreement between raters on the total of individual evaluation criteria items was 96%.
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P values were then calculated as the percent of values in the null distribution larger than the observed % agreement.
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