Taken together the results suggest that the observed ability of DOPE-containing liposomes to mediate cytoplasmic delivery of hydrophilic molecules cannot be explained by a mechanism based on a direct, and non-leaky, fusion between the liposome and endosome membranes.
The observed ability of some of these molecules to inhibit receptor activation shows the potential of our design for the development of effective antagonists with a molecular size comparable to that of the endogenous neurotransmitter l-glutamate.
The holomorphic fungal genus Hypocrea/Trichoderma (Hypocreales, Ascomycota) contains several hundred species comprising both sexually propagating (Hypocrea) as well as apparently mitosporic (Trichoderma) taxa without observed ability to sexual reproduction.
Conversely, not much is known regarding the observed ability of grain amaranth to sustain defoliation.
One possible explanation may be related to the observed ability of Tmp21 to prevent PrP∗ aggregation in the ER independently of mediating its export.
An important consequence of the patterns of bias is that the variance for the observed ability of males to win fertilizations is reduced.
Furthermore TFAP2α induces p21 dependent P53 expression corroborating the observed ability of TFAP2α to induce G1 and G2 cell cycle arrest [ 23, 31].
A membranolytic mechanism of action likely accounts for the observed ability of NRC-03 and NRC-07 to enhance the killing of breast cancer cells by cisplatin.
