Balogh also demonstrated that reducing the DO2 goal of the ICU resuscitation protocol from a supranormal level of 600 ml/min/m2 to a more normal level of 500 ml/min/m2 was associated with a significant reduction in the incidence of ACS, MOF and death.
There we observed supranormal levels of ACDase-specific activity in the bone marrow, peripheral blood mononuclear cells, spleen, and liver.
I didn't observe a high level of success, but it must have been sufficient to maintain their predatory attempts.
Following administration of indomethacin, GFR and effective renal plasma flow (ERPF) fell significantly in HbSS patients but remained unchanged in control subjects [ 14], suggesting that prostaglandins are important in maintaining the supranormal levels of GFR and ERPF observed in SCD.
We previously reported that direct intramuscular injection of non-serotype-2 AAV vectors, especially AAV serotype 1 (AAV1), resulted in expression of supranormal levels of canine F9 in immunodeficient mice.
Expression and secretion of type VII collagen was confirmed with transduced cells exhibiting supranormal levels of protein expression, and ex vivo migration of fibroblasts was restored in functional assays.
The postsynaptic effects of supranormal levels of dopamine induced by cocaine are indeed probably limited by short-term receptor desensitization and/or inter- or intracellular opponent processes [15], [22].
Administration of AT resulted in supranormal levels of AT PP < 0.01 versus placebo and P < 0.01 versus control).
Distributive shock, such as occurs during sepsis and septic shock, however, is associated with an abnormal distribution of microvascular blood flow and metabolic distress in the presence of normal or even supranormal levels of cardiac output.
Exposure of the male fetus to supranormal levels of estrogens, such as diethlylstilbestrol, can result in the above-mentioned reproductive defects.
