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For both fusion peptides, DT-2 and DT-3, we observed a potentiating effect with respect to the inhibitory potency, with Ki values 40- to 80-fold lower than W45.
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This phenomenon has also been observed with exenatide (43, 44) and suggests a potentiating effect, possibly mediated by direct stimulation of the GLP-1 receptor.
A potentiating effect of CPZ on amikacin and tobramycin was not observed, which suggests the occurrence of other resistance mechanisms (Table 1).
Increases in cTnT seem to have a potentiating effect on the risk-predicting potential of increases in both MR-proANP and copeptin.
Our notion about the interaction between TRPV1 and CB1 receptor activation in the meningeal blood flow regulatory effect of anandamide application was supported by the observation, that blockage of CB1 receptors with AM251 has a potentiating effect on anandamide-induced vasodilatation.
Diabetes and radiation primarily damage the retinal capillaries and thus a potentiating effect is not surprising.
As expected, a potentiating effect by ATRA on cytotoxicity was also precluded.
In this scenario, specific PAFR antagonists may have a potentiating effect in enhancing the CDDP sensitivity of ovarian cancer cells.
This could mask a potentiating effect on the cytotoxicity of vincristine and also preclude the use of Gö6976 at effective concentrations.
Similarly, a potentiating effect of chlorpromazine on kanamycin, gentamicin and neomycin, indicating the involvement of an efflux system in the resistance to these aminoglycosides.
Furthermore, we were able to document a potentiating effect of CXCL12 on osteoclast differentiation and activation, both of which were counteracted by AMD3100.
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