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Another example of TNF-induced Notch activation is observed in a mouse pancreatic cancer model where TNF promotes expression of Notch target genes Hes1 and Hey1 (Maniati et al., 2011).
Two additional abnormalities related to peritoneal macrophages and BAT were observed in a mouse background-dependent manner, suggesting involvement of modifying genes in different mouse backgrounds.
However, the hMSCs may also have exerted a neuroprotective effect as was observed in a mouse model for transient cerebral ischemia [31].
Importantly, we show that short-term EE in APP mice recovers normal dendritic morphology of Dcx cells, an effect previously observed in a mouse model of Huntington's disease [51].
No signal was observed using a mouse S100A7/psoriasin sense probe.
Elongated transcripts have also been observed in a mouse model of B-cell leukemia/lymphoma.
A dramatic and clinically relevant gene-environment interaction was also observed in a mouse model of vitamin A deficiency (65).
This early-stage heterogeneity has also been observed in a mouse PGC induction study (Ohinata et al, 2009).
20 Indeed, compartments resembling SLAPs have been observed in a mouse model of L. monocytogenes persistent infection.
Similarly, the protective effect of calpastatin over-expression on endothelial function was also observed in a mouse model of type-2 diabetes, db/db mice (data not shown).
The pregnane derivatives E- and Z-guggulsterone, as observed in a mouse model, act as FXR antagonists, which regulate the expression of a subset of targetgenes.
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