As we did not observe a minimum of two DLTs at the same dose level, the MTD was not reached.
Sample size: considering a rate of ADR-SM possibly not over 1%% of ED patients (personal data), we targeted the enrolment of approximately 5,000 patients (in order to observe a minimum of 30 cases, alpha risk 0.05, power >0.80).
The team will visit the selected households a day in advance to request eligible individuals to observe a minimum of 8 hours of overnight fasting prior to estimation of the fasting capillary blood glucose levels the next morning.
This training will be facilitated by either the Chief Investigator (HH) or the project manager (FC), and all facilitators will observe a minimum of two telephone consultations and two groups before independently delivering program content.
At 0710 UTC on September 18, the Hurricane hunters observed a minimum pressure of 947 mbar just off the northern Honduras coast, which was the basis for the estimated peak intensity of 130 mph (215 km/h).
Two days later, the Hurricane Hunters observed a minimum barometric pressure of 877 mb, as well as estimated peak winds of 325 km/h (200 mph).
On September 15, a ship traveling from St. Thomas to England encountered the hurricane and observed a minimum barometric pressure of 979 mbar (28.90 inHg); this suggested peak winds of 105 mph (165 km/h).
Numerous vessels in its vicinity reported hurricane-force winds; the S.S. Borinquen observed a minimum peripheral pressure of 988 mbar (hPa; 29.18 inHg), the lowest observed pressure associated with the hurricane.
We observed a minimum in the temperature dependence of the o-Ps intensity I3 at ∼20°C for polystyrene specimens subjected to the heating and cooling schedules, but not for the rejuvenated samples.
In these studies, we observed a minimum nanopore-to-microgel radius ratio of ∼0.4 for translocation, which suggests a theoretical limit imposed by the compressibility of the microgel and Coulombic repulsion between the microgels and the pore walls.
