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We observed a marked effect of HIF2α on the modulation of cell size, which was quantified in vitro as well as on histological sections of tumour nodules.
We observed a marked effect on placental development concurrently with this loss of growth potential, with the appearance of large thrombotic lesions in the labyrinth zone.
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In a retrospective study on 32 consecutive patients treated with ECMO for severe respiratory failure, we frequently observed a marked heparin effect on the TEG tracing despite an aPTT ratio and activated clotting time (ACT) within the therapeutic anticoagulation range [16].
We observed a marked lipodystrophy, effect on neuromuscular function, impaired fertility and reduced longevity in the worms exposed to Nef.
After terbutaline administration we observed a marked increase in cardiac index which is a well-known effect of the β-agonists.
We observed a marked imbalance between Ang1 and Ang2 in favor of Ang2 in PCAS patients, and the effect was more prominent in non-survivors.
We observed a marked decrease in migration (Figure S4A).
As expected, we observed a marked reduction in AKT and ERK1/2 MAPK) phosphorylation (figure 6A y B and Figure S6), in accordance with our data on the effects of CPMZ/MCD on IGF1R signaling (figure 2C and D).
Additionally, we observed a marked loss of intracellular fibres upon incubation with AM251.
Concomitantly, we observed a marked reduction of mature ALK phosphorylation.
However, we observed a marked increase in C16:0 ceramide.
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