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We observed a dose dependent reduction of Smad2 phosphorylation in presence of the inhibitor (Fig. 2B).
By testing 4 different concentrations (range 0.1 10µM) we observed a dose dependant inhibition (Fig. 3A B).
Indeed, we observed a dose dependant accumulation of COUP-TFII mRNA in response to increasing amount of the cAMP analog DiB-cAMP (figure 6C).
We also assessed the effect of SFN on telomerase activity and observed a dose- and time-dependent inhibition in breast cancer cells.
We observed a dose- and time-dependent cell growth inhibition with SFN treatment both in MCF-7 and MDA-MB-231 cells (Fig 1A).
Following stimulation of cells with cPAF, we observed a dose- and time-dependent increase in TLR4 gene expression using Real Time PCR analysis (Figure 2a and b).
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We observed a dose-dependent change in heart cell function, an increase in reactive oxygen species and, for titanium dioxide, we also found a less organized myofibrillar structure.
Second, the investigators observed a dose-responsiveness: The more rads, even at low doses, to which the women were exposed, the greater the likelihood of getting breast cancer.
We only observed a dose-dependent increase in response for the IM group.
In addition, we observed a dose-dependent decrease in liver triglyceride levels (Fig. 3C).
We observed a dose-dependent reduction in cell survival in the c-Rel silencing groups (Fig. 2b, 2c).
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