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Because there is substantial crossover of placebo subjects to active treatment, there is very limited opportunity to observe utility values for progressive disease in the presence of BSC, which reflects the current treatment scenario for patients with GIST.
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The experimentally observed utility of this catalyst can be related to the energetically accessible ligand dissociation from the initial Pd(0) species, combined with a low barrier to oxidative addition and sterically unfavourable dimer formation.
Observed utility values for all symptom groups were within 95% CI of the predicted mean utility.
The mean absolute error of predictions increased as the observed utility values decreased.
The minimum observed utility value was −0.13 and the maximum was 1.0.
Observed utility values for all symptom severity groups were all within 95% CI of predicted mean utility.
3, 13 Errors were subsequently reported for the following subsets of observed utility values: utility <0; 0≤ utility <0.25; 0.25≤ utility <0.5; 0.5≤ utility <0.75; 0.75≤ utility ≤1.
The range of the observed utility values varies between 0.30 (worst health state) to 1.0 (best health state) [ 36 ].
Observed utility values from the PLATO study are in the range of reported values for ischemic heart diseases measured by EQ-5D in different published studies.
There was a strong correlation between predicted and observed utilities for all three models.
Overall observed utilities in TOX and REL were normalised relative to a utility=1 for TWiST, providing an average relative utility of 0.90 for TOX and 0.65 for REL.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com