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We conclude from this observation that the limited induction of Ure2p assembly we observe upon addition to fibrillar Ure2p 1–93 or α-synuclein is not due to a nucleating activity per se but rather due to an unspecific process such as those observed upon addition of PEG in protein solutions upon protein crystallization assays [29].
This would explain the high mortality and morphological abnomalities that we observe upon ubiquitous overexpression of VE-cadherin.
This localisation is in agreement with the similar phenotype we observe upon depletion of CG10664 and the mitochondrial elongation factor EfTuM [37].
Taken together, these results suggest that any remodeling or release of soluble factors from the matrix due to the movement of the magnetic beads does not contribute to the enhanced invasion we observe upon mechanical stimulation.
Instead, it is similar to the phenotype we observe upon treatment with a low concentration of DEAB (Figure S2), as well as to a mild version of VAD seen in rat embryos and to partial rescue of Aldh1a2−/− mouse embryos by maternal application of RA [51], [55], [65].
We speculated that the differences in cell death inhibition we could observe upon Atg5 and Atg7 knockdown could mean that autophagosome formation is required for pro-CASP8 activation.
Similar(45)
It is even observed upon the most lofty of Alps.
A similar pattern was observed upon subgroup analysis.
Conversely no yellow brown discoloration is observed upon UV irradiation.
Similarly impaired ion signaling was observed upon gravistimulation.
During cycling a reversible pressure decrease was observed upon charging.
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