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In contrast, as PARO kills through a different mechanism, we did not observe tolerance to SbIII-, MF- or AMB-induced apoptosis in the PARO-resistant mutant.
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The parental and tolerant cells used in the present study were stored at −135 °C, thawed and cultured for 30 days in the absence or presence of PPP at the same concentration as the highest observed tolerance.
However, when observing tolerance, sensitization, dependence, and abstinence, it is clear that pharmacological responses in vivo can be subjected to modulation by homeostatic mechanisms.
An Indigenous health professional observed: Tolerance, perseverance and patience are the core to making change with guidance from elders and elder's spirits.
At higher concentrations, however, pesticides may overwhelm the ability for organisms to upregulate these enzymes or the cost of upregulation may simply be too high; if so, then we would not expect to observe induced tolerance at high pesticide concentrations.
In terms of global tolerances, we observe that all tolerances for the infected erythrocyte are lower.
Third, although we observed no tolerance or tachyphylaxis to fenoldopam in this study, it remains unknown whether longer-term administration will result in tolerance or rebound hypertension.
We observed remarkable tolerance to loop length and sequence diversity as the resulting 38 amino acid EETI-II mutant contained 21 non-native amino acid residues distributed across two loops.
Greater and significant decline could be observed in tolerance index of dry biomass.
Many species face the prospect of their local climate changing so much that their current distribution will be outside their current observed climate tolerance.
After observing treatment tolerance in the LD patients, we administered the upper-dose group (UD) 40 pmol kg−1 min−1 (approximately 8 μg kg−1).
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