This introduces uncertainty, but allows costs and benefits arising in future time periods that were not observed within the timeframe of the trial, to be estimated.
However, due to the restriction in the length of follow-up, the long-term effect of decreasing the number of fractures, might not be observed within the timeframe of the current trial.
Corresponding decreases in pH were observed over the timeframe of experiments, although the pH (Fig. 7D) did not drop considerably below 7. Scale-up of ESC culture is necessary in order to support future developments in the application of hESCs and their differentiated derivatives in regenerative medicine and drug discovery.
Owing to these extended timeframes, seldom do biologists observe the evolution of hybrid mortality in real time.
First, we wanted the students to actually observe evolution within the timeframe of one semester.
The pyrotechnic event, which was originally detected in 2005 at the William Herschel Telescope in the Canary Islands, marks the first time that astronomers have had the luxury of observing the full process of a "tidal disruption event" over an extended timeframe.
We first observed the dormitory on 2 weekday evenings to establish patterns of human traffic, and identify key sites and timeframes to conduct the survey.
Our current interpretation is that the drop in input resistance observed during the same timeframe counteracts the reported increase in IH amplitude (Washio et al., 1999), such that sag amplitude and rebound delay remain constant.
When the timeframe to observe death is fixed or is prolonged to the post-discharge period, these "discharge" biases may be countered.
If so, investigators who view an increase in the number of human subjects principally as a time trend may have instead been observing a timeframe in which vaccines targeting more complex diseases with larger clinical trials were approved later.
Interestingly, we also show that tumors can be observed easily within days, whereas the timeframe in which tumor development is studied in mice is usually weeks up to months.
