Finally, we did not observe inclusion-like staining of anti-TLS-M in the KO brains at 47 weeks (Additional file 1: Figure S3e, Online Resource).
In sporadic and familial ALS patients the most widely observed inclusions immunostain for ubiquitin, and other protein constituents are largely unknown [11].
We also observed inclusions in epithelial cells of a pancreatic duct in R6/2, but did not find any ducts in the HdhQ150/Q150 sections examined for comparison.
In contrast, we did not observe obvious inclusion differences between Htt exon 1 and HttQC.
In contrast to cells expressing mutant VAPB at high levels (Fig. 2A), we did not observe cytoplasmic inclusions of the VAPB protein in motor neurons.
Additionally, similar distributions were observed when inclusion was restricted to one, randomly selected observation per patient (see online supplementary appendix 2).
We observed the inclusion of exon 5 in both examined tissues but found no support for the inclusion of exon 5b.
Majority of the expressed protein was observed in inclusion bodies.
We observed that inclusion of the stabilizer trehalose was critical to preparing µPEDs for later analysis.
It has been observed that inclusion of vibration signal along with thrust force and torque leads to better prediction of drill wear.
Class-specific differences in the pattern of atomic fluctuations along the sequence were observed; however, inclusion of conformational entropy contributions did not change ranking of structural classes.
