Again, we could observe down-regulation of genes which play a key role in cell fate commitment, such as Aebp1 and Chop-10/Ddit3 (Figure 5D).
Furthermore, in QKI-deficient Schwann cells we observe down-regulation of the level of MBP mRNA as well as other Schwann cell maturation markers, p27KIP1 and Krox-20.
In this work, however, we did not observe down-regulation of a gene coding for a cytokinin oxidase over berry development.
Because Gerosa et al. 25 do not observe down-regulation of IL-12 following co-ligation of Dectin-1 with any other TLR apart from TLR2, they suggest that such down-regulation may be due to signaling through TLR2.
We could observe down-regulation of genes coding for proteins related to stress response such as Senescence-Associated Gene 21, a putative gamma-thionin, and a thiazole biosynthetic enzyme (Table 1), as well as up-regulation of peroxidases and mandelonitrile lyase.
But it is authentically observed, down to the most minuscule technical details.
Next time, bring Eric with you" – and, as with Brackenbury, the details of the character are beautifully observed, down to the embroidered jeans and flip-flops.
He is at his best when he mingles factual detail with imaginative symbol; his facts are always closely observed, down to every last glass-tiered factory and every dingy suburban tree.
Deformability was observed down to 43 K.
