The value of w t (a, b) is the probability that we observe character a at position t of the read given that the corresponding character in the reference isoform sequence is b.
Television: I really liked Chris Lilley's 'Angry Boys' on BBC3, which has a cast of really well observed characters.
Immersed in his highly mannered world, you simply can't resist the sharply observed characters and crises of Fantastic Night and Letter From an Unknown Woman.
The exquisite sensibility of Magdalen Nabb's police procedurals has all to do with the feeling of displacement that haunts her sensitively observed characters.
That said, $1.99 a pop seems a reasonable price for what is surely the best webseries around, packed full of pathos, beautifully observed characters and mordant humour.
Though lauded for its evocative sense of place and sharply observed characters, the novel was deemed plotless and confusing by some critics.
And where some songwriters are never able to get beyond the drama of their own lives and diaries, Turner is more than capable of sidestepping his own experience and producing telling little mini-dramas populated by keenly observed characters.
"Let It Rain" is of a piece with Ms. Jaoui's earlier films, "The Taste of Others" and "Look at Me," whose minutely observed characters tend to be thin-skinned, competitive egotists invested in their status in the world of ideas.
While the Hudson Stage cast cannot match the star power that Jeff Daniels, Hope Davis, James Gandolfini and Marcia Gay Harden brought to "God of Carnage" on Broadway, the performances do manage to convey both the humor and the misery in Ms. Reza's ruthlessly observed characters.
Remarkably enough, "The Moonlight Room" relies on other, more substantive, tried-and-true devices: sharply observed characters, a credibly complicated and suspenseful situation with high stakes, and an unashamed realism that in this case depicts a slice of New York City that theatergoers will recognize as authentic (2 10) TriBeCa Playhouse, 111 Reade Street, (212) 868-4444.
