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It is very common to observe a delay between blood or plasma drug concentration and CV effect, resulting in hysteresis observable on a concentration effect plot.
Under these experimental conditions, we did not observe a delay in ABPV propagation, but we did observe a reduction in antimicrobial activity (not shown).
Second, we observe a delay between the subcritical pitchfork bifurcation creating the new attractor state (shown in light blue in Figure 4B) and the system switching into that basin of attraction.
In contrast to the delay in separation of the rDNA, we did not observe a delay in centromere segregation (Supplementary Fig S8), suggesting that the rDNA region is specifically delayed in the eco1 mutant.
We did not detect a reduction in the overall antimicrobial activity in the inhibition-zone assay up to 24 h p.i. (Fig. 6B, samples 6 and 7), but we did observe a delay in ABPV propagation (Fig. 6B).
As shown in Table 3, there were no differences in the eRapa and Eudragit control groups in terms of presence of pituitary tumors (although we did observe a delay in their detection and reduction in size by magnetic resonance imaging (MRI), discussed below).
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We then used the HMGU model to analyze the accretion of zirconium in bones: not only did we observe a delayed aggregation but also to lesser extents than predicted by the ICRP model.
As soon as the source observes a delay, it reduces the rate to the initial value.
We observed a delay in the breakthrough of the early injected water between approximately 0.5 1.0 injected pore volume, at 25 °C only; after that, the oil started to flow.
That's why we observed a delay in osteoclast formation by 5 to 6 days with the bone slices.
We also observed a delay in development in the mtp2 morphants, characterized by a large yolk, decreased embryo size, and decreased melanocyte pigmentation (Figure 6B).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com