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These observations questioned the transcriptional mechanism associated with histone variants and PolII.
These observations questioned the core biological consequences of cyclin D Cdk4/6 progressive hypo-phosphorylation of Rb during early G1 phase.
Our previous observations questioned these face-value assumptions and raised the possibility of an alternate dominate competency domain with acceptable reliability, namely a general professional job performance competency construct [ 16, 17].
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Several observations question this hypothesis.
These observations question the previously straightforward role for DT-diaphorase in the metabolic activation of EO9.
Furthermore, new observations question whether this mechanism is specifically relevant to liver carcinogenesis in rodents (Guyton et al. 2009).
These observations question the rationale of continued recommendation of SP as either standby therapy or combination therapy with quinine for the treatment of P. falciparum malaria in travelers.
These observations question the timing for using hemoadsorption in severe sepsis, since the delay between the onset of sepsis and a therapeutic decision might be highly variable.
As discussed below (Section 4.2), these combined observations question the dominance of Rat1 in PAS associated termination and argue for the existence of additional termination factors.
This observation questioned whether genomic imbalances influence transcription at the global transcriptional level [ 13].
This observation questions the nutrient utilization of potato by the broilers.
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