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The findings extend and strengthen earlier observations of loss of peroxisomes.
Observations of loss of paclitaxel killing with loss of Bim have been made in lymphocytes, 17 neuroblastoma, 25 and non-small cell lung cancer.
To rationalize the observations of loss of collagen density in vivo, the effect of extracellular GzmB on fibroblast function and FN fragmentation was investigated in vitro.
Our observations of MFs in vivo are consistent with our previous observations of loss of stromule morphology and motility in the presence of MF inhibitors.
Our observations of loss of EpEx expression on the plasma membrane of ATC is in accord with an earlier report on EpCAM expression in TC by Ensinger et al., [ 29].
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At day 8.5, untreated mice completely rejected the graft confirming by daily observation of loss of skin graft and erosion.
This corroborates the observation of loss of stability (lowering of the erosion threshold) during this treatment as described above.
The advent of new molecular biological and genetic information coupled with powerful technologies has begun to allow the study of this problem at a level beyond that of the purely morphologic, as in the observation of loss of heterozygosity at the BRCA1 and TP53 loci in an ovarian "carcinoma in situ" lesion from a BRCA1 mutation carrier [18].
MCS is an exception to the general observation of loss of health status over time.
Hence, our simulations agree with the experimental observation of loss of NANOG heterogeneity with cells cultured in 2i/3i media.
The observation of loss of CHIA expression was therefore suggested as a clinical marker of corpus atrophy (Nookaew et al. 2013).
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