However, based on previous observations, the introduction of appropriate substitutions onto the sulfamate-bearing ring in 51 would be expected to improve inhibitory activity against both enzymes, indicating the feasibility of a DASI based on the vorozole template.
This is consistent with the observation that introduction of the R1070A mutation into wild-type CFTR also did not affect its maturation (data not shown).
In line with this suggestion was the observation that introduction of two basic residues into the transmembrane segment resulted in mislocalisation to the cytosol.
Other evidence suggesting that ΔF508/ΔNBD2 (Δ1173−1480) was more difficult to rescue was the observation that introduction of V510D into the mutant yielded lower levels of mature protein compared to the ΔF508/ΔNBD2/V510D (Δ1197−1480) construct.
22, 30 This is consistent with the observation that introduction of a mismatch at position 1 is tolerated and even potentiates the enzymatic activity of the effector complex in vitro.
These results are consistent with the observation that introduction of miR-568 into MDA-MB-231 cells suppressed a mesenchymal phenotype and concurrently improved epithelial marker expression in these cells.
We reported previously that dysadherin has an anti-cell – cell adhesion function and downregulates E-cadherin, on the basis of the observation that introduction of dysadherin induced decreased the protein expression and function of E-cadherin without affecting its transcription (Ino et al, 2002).
These observations motivate the introduction of the following dual stochastic subgradient descent algorithm.
The features of the rupture propagation in case A2 with the free surface were consistent with the observations summarized in "Introduction" section.
When (D_{text{c}}) was 0.1 m, the features of the rupture propagation in cases with (S_{text{H}}) of either 1.2 or 1.6 were similar to the observations summarized in "Introduction" section.
