All these data, together with our observation of a marked reduction of DOR expression in skeletal muscle from ZDF rats, lead us to propose that DOR participates in the pathophysiology of type 2 diabetes.
In the periphery, two main observations were recorded: (i) a marked decrease in blood NO production which likely limits the NO trypanocidal activity; and (ii) an increased activity of arginase favouring the synthesis of polyamines necessary for trypanosome growth [11].
Kaplan-Meier curves were used to visualize survival probabilities; they decrease when a death occurs, while a censored observation is marked by a tick-mark, leaving the curve unchanged.
Given the safety record of AQ when used as a prophylaxis, our observations of marked falls in neutrophil counts in the AQ+SP group requires further scrutiny.
Twenty goats of the group of 82 were randomly selected (10 horned and 10 hornless) for individual observations, and marked across their back with a marker spray for animals and dark goats were marked with different coloured collars.
Despite such high stability at the meta-community scale, our results indicate remarkably high temporal turnover of species at the local scale, a phenomenon that is confirmed by observations showing marked changes in the population sizes of individual fynbos species after particular fires [18], [31], [32].
In agreement with these observations, the marked reduction in E-cadherin expression observed in DU145R80 cells and the acquisition of EMT features are probably also responsible for the ability of DU145R80 cells to survive under conditions that reproduce the bloodstream, such as anoikis conditions.
There are few glimpses of the cold, wounded observations that marked the poet's first books, more than a quarter-century ago — the canny social malaise, the slightly bitter tone, the whiff of misery, the suspicion of what the world offers, all reminiscent of Larkin without being slavishly indebted.
Like Fletcher's previous heroines, Corrag is steeped in the landscapes that surround her and her observations are marked by the same lyricism as those of her predecessors.
This would also be compatible with the very slow growth of the host plant, for which qualitative observations from marked trees followed for several years (1989 1997) suggest that they will not flower before reaching tens of years in age.
