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The limitations of this study relate to the observational methodological design.
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For observational studies, methodological quality will be assessed against the Downs and Black Scale.
Kuhn initially used the term holistically to capture methodological, observational and conceptual disparities between successive scientific paradigms that he had encountered in his historical investigations into the development of the natural sciences (Kuhn 1962, 148 150).
Field notes were made immediately after each interview including methodological, observational and reflexive notes.
Inference of adverse drug effects from observational data presents methodological challenges, especially confounding of the association of drug allocation with outcome by susceptibility.
Reporting clarity was evaluated with the STROBE observational checklist and methodological quality with the NICE adapted Graphical Appraisal Tool for Epidemiological studies (GATE) [ 27].
First, this study was processed in a retrospective observational manner; thus, methodological deficiencies in assessing risk factors for MDR AB acquisition may lead to biased estimates or erroneous associations.
These associations may result from bidirectional relationships or they may be the outcome of a third factor affecting both glucose metabolism and breathing during sleep, such as weight gain during pregnancy or psychosocial stress both areas that warrant further investigation using observational causal inference methodological tools (49).
However, several unconsidered methodological and observational -related limitations may lead to misinterpretation of the satellite-derived signals.
However, observational studies suffer from methodological drawbacks, which prevent meaningful conclusions and represent a serious limitation when data from different reports are pooled for systematic reviews and meta-analyses.
Furthermore, designing observational studies using high methodological rigor both during the design phase, but also during the analysis phase are needed.
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