The relevance of these observations to basic aging research was reinforced by the finding that loss of insulin / insulin-like signaling (IIS), the most robust pro-longevity genetic manipulation currently known, partly influenced longevity by modulating HSP expression, particularly the low molecular weight small HSPs [ 10, 12, 13].
This observation was first made in a very small number of carefully selected normal samples [ 34] and has since been widely replicated, studied functionally and mechanistically, and is now the subject of studies applying this basic observation to treatment.
We used this basic observation to demonstrate that it is possible to adjust for each given set of DNA sequences a "good" additive SR function, which leads to significantly increased phylogenetic reconstruction accuracy, compared to other additive SR functions.
The scientific principles and technologies involved in making the transition from a basic biological observation to the creation of a new drug emphasizing molecular and genetic issues.
Gather yourself, use open body language and friendly, non-threating posture, and lead with a basic question or observation to open up conversation.
We investigated the following three characteristics of the MRs. First, we used Swarm observations to confirm their basic characteristics obtained from the Challenging Minisatellite Payload satellite.
In the Central African Republic (CAR), after years of conflict that have taken a heavy toll – destroying most of the infrastructure and cutting access to basic services – observations on the ground spoke of torrential downpours making the survey teams' journey treacherous.
It is clearly a doodle, unattached to observation, a basic symbolic type like the birds in the margins of medieval manuscripts.
Individual research training awards and institutional training grant programs, both pre- and post-doctoral, could involve mentoring networks of experienced investigators working at various levels of observation from basic to population aging biology.
I make these observations to underscore that the basic values of most Americans when it comes to questions of surveillance and privacy converge far more than the crude characterizations that have emerged over the last several months.
